Frontiers in Psychiatry (Apr 2022)
Alternations in Dynamic and Static Functional Connectivity Density in Chronic Smokers
- Zhengui Yang,
- Zhengui Yang,
- Zhengui Yang,
- Zhengui Yang,
- Zhengui Yang,
- Zhengui Yang,
- Zhengui Yang,
- Mengmeng Wen,
- Mengmeng Wen,
- Mengmeng Wen,
- Mengmeng Wen,
- Mengmeng Wen,
- Mengmeng Wen,
- Mengmeng Wen,
- Yarui Wei,
- Yarui Wei,
- Yarui Wei,
- Yarui Wei,
- Yarui Wei,
- Yarui Wei,
- Yarui Wei,
- Huiyu Huang,
- Huiyu Huang,
- Huiyu Huang,
- Huiyu Huang,
- Huiyu Huang,
- Huiyu Huang,
- Huiyu Huang,
- Ruiping Zheng,
- Ruiping Zheng,
- Ruiping Zheng,
- Ruiping Zheng,
- Ruiping Zheng,
- Ruiping Zheng,
- Ruiping Zheng,
- Weijian Wang,
- Weijian Wang,
- Weijian Wang,
- Weijian Wang,
- Weijian Wang,
- Weijian Wang,
- Weijian Wang,
- Xinyu Gao,
- Xinyu Gao,
- Xinyu Gao,
- Xinyu Gao,
- Xinyu Gao,
- Xinyu Gao,
- Xinyu Gao,
- Mengzhe Zhang,
- Mengzhe Zhang,
- Mengzhe Zhang,
- Mengzhe Zhang,
- Mengzhe Zhang,
- Mengzhe Zhang,
- Mengzhe Zhang,
- Jingliang Cheng,
- Jingliang Cheng,
- Jingliang Cheng,
- Jingliang Cheng,
- Jingliang Cheng,
- Jingliang Cheng,
- Jingliang Cheng,
- Shaoqiang Han,
- Shaoqiang Han,
- Shaoqiang Han,
- Shaoqiang Han,
- Shaoqiang Han,
- Shaoqiang Han,
- Shaoqiang Han,
- Yong Zhang,
- Yong Zhang,
- Yong Zhang,
- Yong Zhang,
- Yong Zhang,
- Yong Zhang,
- Yong Zhang
Affiliations
- Zhengui Yang
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Zhengui Yang
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Zhengui Yang
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Zhengui Yang
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Zhengui Yang
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Zhengui Yang
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Zhengui Yang
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Mengmeng Wen
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Mengmeng Wen
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Mengmeng Wen
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Mengmeng Wen
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Mengmeng Wen
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Mengmeng Wen
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Mengmeng Wen
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Yarui Wei
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Yarui Wei
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Yarui Wei
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Yarui Wei
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Yarui Wei
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Yarui Wei
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Yarui Wei
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Huiyu Huang
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Huiyu Huang
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Huiyu Huang
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Huiyu Huang
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Huiyu Huang
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Huiyu Huang
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Huiyu Huang
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Ruiping Zheng
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Ruiping Zheng
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Ruiping Zheng
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Ruiping Zheng
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Ruiping Zheng
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Ruiping Zheng
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Ruiping Zheng
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Weijian Wang
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Weijian Wang
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Weijian Wang
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Weijian Wang
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Weijian Wang
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Weijian Wang
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Weijian Wang
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Xinyu Gao
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Xinyu Gao
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Xinyu Gao
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Xinyu Gao
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Xinyu Gao
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Xinyu Gao
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Xinyu Gao
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Mengzhe Zhang
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Mengzhe Zhang
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Mengzhe Zhang
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Mengzhe Zhang
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Mengzhe Zhang
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Mengzhe Zhang
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Mengzhe Zhang
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Jingliang Cheng
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Jingliang Cheng
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Jingliang Cheng
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Jingliang Cheng
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Jingliang Cheng
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Jingliang Cheng
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Jingliang Cheng
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Shaoqiang Han
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Shaoqiang Han
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Shaoqiang Han
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Shaoqiang Han
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Shaoqiang Han
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Shaoqiang Han
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Shaoqiang Han
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Yong Zhang
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Yong Zhang
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Yong Zhang
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Yong Zhang
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Yong Zhang
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Yong Zhang
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Yong Zhang
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- DOI
- https://doi.org/10.3389/fpsyt.2022.843254
- Journal volume & issue
-
Vol. 13
Abstract
Previous studies have implicated abnormal functional coordination in brain regions of smokers. Neuroimaging studies demonstrated alternations in brain connectivity by using the resting-state functional connectivity (rsFC) method which arbitrarily chooses specific networks or seed regions as priori selections and cannot provide a full picture of the FC changes in chronic smokers. The aim of this study was to investigate the whole-brain functional coordination measured by functional connectivity density (FCD). As the variance of brain activity, dynamic FCD (dFCD) was performed to investigate dynamic changes of whole-brain integration in chronic smokers. In total, 120 chronic smokers and 56 nonsmokers were recruited, and static FCD and dFCD were performed to investigate aberrance of whole-brain functional coordination. Shared aberrance in visual areas has been found in both static and dFCD study in chronic smokers. Furthermore, the results exhibited that both heavy and light smokers demonstrated decreased dFCD in the visual cortex and left precuneus, and also increased dFCD in the right orbitofrontal cortex, left caudate, right putamen, and left thalamus compared with nonsmokers. In addition, alternations of dFCD have been found between heavy and light smokers. Furthermore, the dFCD variations showed significant positive correlation with smoking-related behaviors. The results demonstrated that chronic smokers not only have some initial areas, but also have some regions associated with severity of cigarette smoking. Lastly, dFCD could provide more subtle variations in chronic smokers, and the combination of static and dFCD may deepen our understanding of the brain alternations in chronic smokers.
Keywords
