The FANCD2–FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2

Chih-Chao Liang; Zhuolun Li; David Lopez-Martinez; William V. Nicholson; Catherine Vénien-Bryan; Martin A. Cohn

doi:10.1038/ncomms12124

Nature Communications (Jul 2016)

The FANCD2–FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2

Chih-Chao Liang,
Zhuolun Li,
David Lopez-Martinez,
William V. Nicholson,
Catherine Vénien-Bryan,
Martin A. Cohn

Affiliations

Chih-Chao Liang: Department of Biochemistry, University of Oxford
Zhuolun Li: Institute of Mineralogy, Materials Physics and Cosmochemistry, UMR 7590, UPMC, CNRS, IRD, MNHN
David Lopez-Martinez: Department of Biochemistry, University of Oxford
William V. Nicholson: Department of Biochemistry, University of Oxford
Catherine Vénien-Bryan: Institute of Mineralogy, Materials Physics and Cosmochemistry, UMR 7590, UPMC, CNRS, IRD, MNHN
Martin A. Cohn: Department of Biochemistry, University of Oxford

DOI: https://doi.org/10.1038/ncomms12124
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 10

Abstract

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FANCD2 and FANCI are essential components of the Fanconi anaemia DNA damage repair pathway. Here the authors present the cryo-EM structure of the FANCD2-FANCI complex, providing insight into how the complex is recruited to stalled replication forks.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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