Nature Communications (May 2021)
The impact of chromosomal fusions on 3D genome folding and recombination in the germ line
- Covadonga Vara,
- Andreu Paytuví-Gallart,
- Yasmina Cuartero,
- Lucía Álvarez-González,
- Laia Marín-Gual,
- Francisca Garcia,
- Beatriu Florit-Sabater,
- Laia Capilla,
- Rosa Ana Sanchéz-Guillén,
- Zaida Sarrate,
- Riccardo Aiese Cigliano,
- Walter Sanseverino,
- Jeremy B. Searle,
- Jacint Ventura,
- Marc A. Marti-Renom,
- François Le Dily,
- Aurora Ruiz-Herrera
Affiliations
- Covadonga Vara
- Departament de Biologia Cellular, Fisiologia i Immunologia, Universitat Autònoma de Barcelona
- Andreu Paytuví-Gallart
- Departament de Biologia Cellular, Fisiologia i Immunologia, Universitat Autònoma de Barcelona
- Yasmina Cuartero
- Centre for Genomic Regulation, The Barcelona Institute for Science and Technology
- Lucía Álvarez-González
- Departament de Biologia Cellular, Fisiologia i Immunologia, Universitat Autònoma de Barcelona
- Laia Marín-Gual
- Departament de Biologia Cellular, Fisiologia i Immunologia, Universitat Autònoma de Barcelona
- Francisca Garcia
- Servei de Cultius Cel.lulars, Universitat Autònoma de Barcelona
- Beatriu Florit-Sabater
- Departament de Biologia Cellular, Fisiologia i Immunologia, Universitat Autònoma de Barcelona
- Laia Capilla
- Genome Integrity and Instability Group, Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona
- Rosa Ana Sanchéz-Guillén
- Departament de Biologia Cellular, Fisiologia i Immunologia, Universitat Autònoma de Barcelona
- Zaida Sarrate
- Departament de Biologia Cellular, Fisiologia i Immunologia, Universitat Autònoma de Barcelona
- Riccardo Aiese Cigliano
- Sequentia Biotech
- Walter Sanseverino
- Sequentia Biotech
- Jeremy B. Searle
- Department of Ecology and Evolutionary Biology, Corson Hall, Cornell University
- Jacint Ventura
- Departament de Biologia Animal, Biologia Vegetal i Ecologia, Universitat Autònoma de Barcelona
- Marc A. Marti-Renom
- Centre for Genomic Regulation, The Barcelona Institute for Science and Technology
- François Le Dily
- Centre for Genomic Regulation, The Barcelona Institute for Science and Technology
- Aurora Ruiz-Herrera
- Departament de Biologia Cellular, Fisiologia i Immunologia, Universitat Autònoma de Barcelona
- DOI
- https://doi.org/10.1038/s41467-021-23270-1
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
How mammalian genomes are packaged and the heritability of structural variations in genome folding is incomplete. Here, the authors investigate the impact of chromosomal fusions on three-dimensional genome topology and meiotic recombination, highlighting the implications of large-scale genome reorganizations on genome function, evolution, and fertility.
