Lesion environments direct transplanted neural progenitors towards a wound repair astroglial phenotype in mice

T. M. O’Shea; Y. Ao; S. Wang; A. L. Wollenberg; J. H. Kim; R. A. Ramos Espinoza; A. Czechanski; L. G. Reinholdt; T. J. Deming; M. V. Sofroniew

doi:10.1038/s41467-022-33382-x

Nature Communications (Sep 2022)

Lesion environments direct transplanted neural progenitors towards a wound repair astroglial phenotype in mice

T. M. O’Shea,
Y. Ao,
S. Wang,
A. L. Wollenberg,
J. H. Kim,
R. A. Ramos Espinoza,
A. Czechanski,
L. G. Reinholdt,
T. J. Deming,
M. V. Sofroniew

Affiliations

T. M. O’Shea: Department of Neurobiology, David Geffen School of Medicine, University of California
Y. Ao: Department of Neurobiology, David Geffen School of Medicine, University of California
S. Wang: Department of Neurobiology, David Geffen School of Medicine, University of California
A. L. Wollenberg: Department of Chemistry and Biochemistry, University of California Los Angeles
J. H. Kim: Department of Neurobiology, David Geffen School of Medicine, University of California
R. A. Ramos Espinoza: Department of Biomedical Engineering, Boston University
A. Czechanski: The Jackson Laboratory
L. G. Reinholdt: The Jackson Laboratory
T. J. Deming: Department of Chemistry and Biochemistry, University of California Los Angeles
M. V. Sofroniew: Department of Neurobiology, David Geffen School of Medicine, University of California

DOI: https://doi.org/10.1038/s41467-022-33382-x
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 22

Abstract

Read online

Effects of lesion environments on transplanted neural progenitor cells (NPC) are not well characterized. Here, the authors show that NPC transplanted into CNS lesions generate cells that share transcriptional and functional features with host wound repair astroglia in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal