Leukemia Research Reports (Jan 2020)

Myasthenia Gravis and Large Granular Lymphocytic Leukemia: a rare association

  • Yumeng Zhang, MD,
  • Christa Varnadoe, BS,
  • Ankita Tandon, DO,
  • Peter Forsyth, MD,
  • Rami Komrokji, MD,
  • Lubomir Sokol, MD

Journal volume & issue
Vol. 14
p. 100226

Abstract

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Myasthenia gravis (MG) is an autoimmune neuromuscular junction disorder sometimes observed in hematologic malignancies as a paraneoplastic syndrome. T-cell Large Granular Lymphocytic Leukemia (T-LGLL) is a rare lymphoproliferative clonal frequently associated with autoimmune disorders. Here we report two patients with T-LGLL who developed MG. In both patients the MG was bulbar without generalized weakness and did not involve the thymus. The treatment of T-LGLL led to the resolution of MG symptoms and decrease in acetylcholine receptor antibody titers in both patients suggesting a causative association.

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