A preliminary study of diffusion tensor imaging in root entry zone of primary trigeminal neuralgia

Yiwen Wang; Yiwen Wang; Yiwen Wang; Yiwen Wang; Yiwen Wang; Danni Wang; Yingwei Wu; Ce Zhu; Ce Zhu; Ce Zhu; Ce Zhu; Ce Zhu; Wenbin Wei; Wenbin Wei; Wenbin Wei; Wenbin Wei; Wenbin Wei; Yao Li; Lingzhi Li; Wantao Chen; Wantao Chen; Wantao Chen; Wantao Chen; Wantao Chen; Minjie Chen; Minjie Chen; Minjie Chen; Minjie Chen; Minjie Chen

doi:10.3389/fnana.2023.1112662

Frontiers in Neuroanatomy (Mar 2023)

A preliminary study of diffusion tensor imaging in root entry zone of primary trigeminal neuralgia

Yiwen Wang,
Yiwen Wang,
Yiwen Wang,
Yiwen Wang,
Yiwen Wang,
Danni Wang,
Yingwei Wu,
Ce Zhu,
Ce Zhu,
Ce Zhu,
Ce Zhu,
Ce Zhu,
Wenbin Wei,
Wenbin Wei,
Wenbin Wei,
Wenbin Wei,
Wenbin Wei,
Yao Li,
Lingzhi Li,
Wantao Chen,
Wantao Chen,
Wantao Chen,
Wantao Chen,
Wantao Chen,
Minjie Chen,
Minjie Chen,
Minjie Chen,
Minjie Chen,
Minjie Chen

Affiliations

Yiwen Wang: Department of Oral Surgery, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Yiwen Wang: College of Stomatology, Shanghai Jiao Tong University, Shanghai, China
Yiwen Wang: National Center for Stomatology, Shanghai, China
Yiwen Wang: National Clinical Research Center for Oral Diseases, Shanghai, China
Yiwen Wang: Shanghai Key Laboratory of Stomatology, Shanghai, China
Danni Wang: School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China
Yingwei Wu: Department of Radiology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Ce Zhu: College of Stomatology, Shanghai Jiao Tong University, Shanghai, China
Ce Zhu: National Center for Stomatology, Shanghai, China
Ce Zhu: National Clinical Research Center for Oral Diseases, Shanghai, China
Ce Zhu: Shanghai Key Laboratory of Stomatology, Shanghai, China
Ce Zhu: Department of Preventive Dentistry, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Wenbin Wei: Department of Oral Surgery, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Wenbin Wei: College of Stomatology, Shanghai Jiao Tong University, Shanghai, China
Wenbin Wei: National Center for Stomatology, Shanghai, China
Wenbin Wei: National Clinical Research Center for Oral Diseases, Shanghai, China
Wenbin Wei: Shanghai Key Laboratory of Stomatology, Shanghai, China
Yao Li: School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China
Lingzhi Li: Department of Stomatology, Huashan Hospital, Fudan University, Shanghai, China
Wantao Chen: College of Stomatology, Shanghai Jiao Tong University, Shanghai, China
Wantao Chen: National Center for Stomatology, Shanghai, China
Wantao Chen: National Clinical Research Center for Oral Diseases, Shanghai, China
Wantao Chen: Shanghai Key Laboratory of Stomatology, Shanghai, China
Wantao Chen: 0Department of Oral and Maxillofacial-Head & Neck Oncology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Minjie Chen: Department of Oral Surgery, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Minjie Chen: College of Stomatology, Shanghai Jiao Tong University, Shanghai, China
Minjie Chen: National Center for Stomatology, Shanghai, China
Minjie Chen: National Clinical Research Center for Oral Diseases, Shanghai, China
Minjie Chen: Shanghai Key Laboratory of Stomatology, Shanghai, China

DOI: https://doi.org/10.3389/fnana.2023.1112662
Journal volume & issue: Vol. 17

Abstract

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ObjectivePrimary Trigeminal Neuralgia (PTN) is a common and refractory neurological disease. Conventional vascular compression theory could not completely explain the etiology and pathogenesis of PTN. This study used diffusion tensor imaging (DTI) to demonstrate the microstructural changes of root entry zone (REZ) region in PTN patients.Materials and methodsDTI sequences was performed on PTN patients and healthy controls (HCs). Clinical data included affected side, disease course and visual analogue scale (VAS) were collected. Quantitative DTI variables such as FA, MD, AD and RD of the root entry/Exit zone (REZ) were measured and compared in PTN/HCs, affected/unaffected side, and pre/post operation groups. The PCoA was established to conduct overall differences between PTN group and the HCs.ResultsA total of 17 patients with PTN (mean age 59.29 ± 8.53; 5 men) and 34 HCs (mean age 57.70 ± 6.37; 10 men) were included. Lower FA value of the affected side of PTN group was observed compared to the unaffected side and the HCs (p = 0.001), whereas the values of MD, AD and RD were significantly increased (p < 0.001). Moreover, the decrease of FA value was recovered post operation. PCoA results of the comprehensive indexes can significantly distinguish PTN group from HCs (r = 0.500, p < 0.001).ConclusionQuantitative variables derived from DTI in REZ had significantly different profiles between PTN patients and HCs, which were associated with VAS situation and the disease course of PTN. The comprehensive index established on DTI variables were of great potential to reveal the microstructure changes in PTN patients and predict the therapeutic effect.

Published in Frontiers in Neuroanatomy

ISSN: 1662-5129 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry; Science: Human anatomy
Website: https://www.frontiersin.org/journals/neuroanatomy

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