Frontiers in Oncology (Apr 2023)

RET rearrangement-positive pancreatic cancer has remarkable response to pralsetinib: a case report

  • Tongyi Zhang,
  • Hongwei Wang,
  • Zhiwei Cai,
  • Siqi Zhang,
  • Chongyi Jiang,
  • Chongyi Jiang

DOI
https://doi.org/10.3389/fonc.2023.1078076
Journal volume & issue
Vol. 13

Abstract

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Patients with metastatic pancreatic cancer have limited treatment options and a dismal prognosis. While RET fusion is rare (0.6%) in pancreatic cancer, the efficacy of RET-targeted treatment in patients with TRIM33-RET fusion has not been previously reported. Herein, we presented a case of a 68-year-old man with pancreatic cancer harboring TRIM33-RET fusion who responded remarkably to pralsetinib despite being intolerant to chemotherapy. To our knowledge, this is the first report on the clinical value of a single TRIM33-RET fusion in pancreatic cancer, which may benefit from the targeted therapy.

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