Nature Communications (Jan 2021)

Boosting anti-PD-1 therapy with metformin-loaded macrophage-derived microparticles

  • Zhaohan Wei,
  • Xiaoqiong Zhang,
  • Tuying Yong,
  • Nana Bie,
  • Guiting Zhan,
  • Xin Li,
  • Qingle Liang,
  • Jianye Li,
  • Jingjing Yu,
  • Gang Huang,
  • Yuchen Yan,
  • Zelong Zhang,
  • Bixiang Zhang,
  • Lu Gan,
  • Bo Huang,
  • Xiangliang Yang

DOI
https://doi.org/10.1038/s41467-020-20723-x
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 20

Abstract

Read online

Durable response rate to anti-PD-1/PD-L1 therapy remains relatively low in patients with cancer. Here the authors show that metformin-loaded mannose-modified macrophage-derived microparticles reprogram the tumor immune microenvironment and improve responses to anti-PD-1 therapy.