TREM-1 links dyslipidemia to inflammation and lipid deposition in atherosclerosis

Daniel Zysset; Benjamin Weber; Silvia Rihs; Jennifer Brasseit; Stefan Freigang; Carsten Riether; Yara Banz; Adelheid Cerwenka; Cedric Simillion; Pedro Marques-Vidal; Adrian F. Ochsenbein; Leslie Saurer; Christoph Mueller

doi:10.1038/ncomms13151

Nature Communications (Oct 2016)

TREM-1 links dyslipidemia to inflammation and lipid deposition in atherosclerosis

Daniel Zysset,
Benjamin Weber,
Silvia Rihs,
Jennifer Brasseit,
Stefan Freigang,
Carsten Riether,
Yara Banz,
Adelheid Cerwenka,
Cedric Simillion,
Pedro Marques-Vidal,
Adrian F. Ochsenbein,
Leslie Saurer,
Christoph Mueller

Affiliations

Daniel Zysset: Division of Experimental Pathology, Institute of Pathology, University of Bern
Benjamin Weber: Division of Experimental Pathology, Institute of Pathology, University of Bern
Silvia Rihs: Division of Experimental Pathology, Institute of Pathology, University of Bern
Jennifer Brasseit: Division of Experimental Pathology, Institute of Pathology, University of Bern
Stefan Freigang: Division of Experimental Pathology, Institute of Pathology, University of Bern
Carsten Riether: Department of Clinical Research, Tumor Immunology, University of Bern
Yara Banz: Division of Clinical Pathology, Institute of Pathology, University of Bern
Adelheid Cerwenka: Innate Immunity Group, German Cancer Research Center
Cedric Simillion: Department of Clinical Research, Tumor Immunology, University of Bern
Pedro Marques-Vidal: Department of Internal Medicine, Internal Medicine, Lausanne University Hospital
Adrian F. Ochsenbein: Department of Clinical Research, Tumor Immunology, University of Bern
Leslie Saurer: Division of Experimental Pathology, Institute of Pathology, University of Bern
Christoph Mueller: Division of Experimental Pathology, Institute of Pathology, University of Bern

DOI: https://doi.org/10.1038/ncomms13151
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 16

Abstract

Read online

TREM-1 is a receptor that amplifies acute pro-inflammatory responses in infection. Here the authors show that TREM-1 plays an important role in atherosclerosis, a chronic and non-infectious disease, by critically skewing myelopoiesis towards preferential monocyte differentiation and by contributing to CD36-driven cellular lipid accumulation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal