Nature Communications (Jan 2021)

Structural basis of ribosomal RNA transcription regulation

  • Yeonoh Shin,
  • M. Zuhaib Qayyum,
  • Danil Pupov,
  • Daria Esyunina,
  • Andrey Kulbachinskiy,
  • Katsuhiko S. Murakami

DOI
https://doi.org/10.1038/s41467-020-20776-y
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

Read online

Ribosomal RNA (rRNA) expression is regulated at the initiation stage of RNA synthesis. Here, the authors report cryo-EM structures of E. coli RNA polymerase and rRNA promoter complex with DksA/ppGpp on the way to open complex formation, identifying key steps in promoter recognition and opening.