Nature Communications (Jul 2019)
Decreased maternal serum acetate and impaired fetal thymic and regulatory T cell development in preeclampsia
- Mingjing Hu,
- David Eviston,
- Peter Hsu,
- Eliana Mariño,
- Ann Chidgey,
- Brigitte Santner-Nanan,
- Kahlia Wong,
- James L. Richards,
- Yu Anne Yap,
- Fiona Collier,
- Ann Quinton,
- Steven Joung,
- Michael Peek,
- Ron Benzie,
- Laurence Macia,
- David Wilson,
- Ann-Louise Ponsonby,
- Mimi L. K. Tang,
- Martin O’Hely,
- Norelle L. Daly,
- Charles R. Mackay,
- Jane E. Dahlstrom,
- The BIS Investigator Group,
- Peter Vuillermin,
- Ralph Nanan
Affiliations
- Mingjing Hu
- Charles Perkins Centre Nepean, The University of Sydney
- David Eviston
- Sydney Medical School Nepean, The University of Sydney
- Peter Hsu
- Discipline of Paediatrics and Child Health, Sydney Medical School, The University of Sydney
- Eliana Mariño
- Infection and Immunity Program, Biomedicine Discovery Institute, Monash University
- Ann Chidgey
- Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash University
- Brigitte Santner-Nanan
- Charles Perkins Centre Nepean, The University of Sydney
- Kahlia Wong
- Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash University
- James L. Richards
- Infection and Immunity Program, Biomedicine Discovery Institute, Monash University
- Yu Anne Yap
- Infection and Immunity Program, Biomedicine Discovery Institute, Monash University
- Fiona Collier
- Deakin University
- Ann Quinton
- Sydney Medical School Nepean, The University of Sydney
- Steven Joung
- Sydney Medical School Nepean, The University of Sydney
- Michael Peek
- Sydney Medical School Nepean, The University of Sydney
- Ron Benzie
- Nepean Hospital
- Laurence Macia
- Department of Pathology, School of Medical Sciences, Charles Perkins Centre, The University of Sydney
- David Wilson
- Centre for Molecular Therapeutics, AITHM, James Cook University
- Ann-Louise Ponsonby
- Murdoch Children’s Research Institute
- Mimi L. K. Tang
- Murdoch Children’s Research Institute
- Martin O’Hely
- Deakin University
- Norelle L. Daly
- Centre for Molecular Therapeutics, AITHM, James Cook University
- Charles R. Mackay
- Infection and Immunity Program, Biomedicine Discovery Institute, Monash University
- Jane E. Dahlstrom
- Anatomical Pathology, ACT Pathology, Canberra Hospital and ANU Medical School, College of Health and Medicine, The Australian National University
- The BIS Investigator Group
- Peter Vuillermin
- Deakin University
- Ralph Nanan
- Charles Perkins Centre Nepean, The University of Sydney
- DOI
- https://doi.org/10.1038/s41467-019-10703-1
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Maternal immunological dysregulation might affect the immunological development of the fetus. Here the authors show that decreased maternal acetate is associated with preeclampsia, impaired fetal thymic output and regulatory T cell development.
