Communications Biology (May 2022)
Short-chain fatty acids promote the effect of environmental signals on the gut microbiome and metabolome in mice
- Francesco Marrocco,
- Mary Delli Carpini,
- Stefano Garofalo,
- Ottavia Giampaoli,
- Eleonora De Felice,
- Maria Amalia Di Castro,
- Laura Maggi,
- Ferdinando Scavizzi,
- Marcello Raspa,
- Federico Marini,
- Alberta Tomassini,
- Roberta Nicolosi,
- Carolina Cason,
- Flavia Trettel,
- Alfredo Miccheli,
- Valerio Iebba,
- Giuseppina D’Alessandro,
- Cristina Limatola
Affiliations
- Francesco Marrocco
- Department of Physiology and Pharmacology, Sapienza University
- Mary Delli Carpini
- Department of Physiology and Pharmacology, Sapienza University
- Stefano Garofalo
- Department of Physiology and Pharmacology, Sapienza University
- Ottavia Giampaoli
- Department of Chemistry, Sapienza University of Rome
- Eleonora De Felice
- Department of Physiology and Pharmacology, Sapienza University
- Maria Amalia Di Castro
- Department of Physiology and Pharmacology, Sapienza University
- Laura Maggi
- Department of Physiology and Pharmacology, Sapienza University
- Ferdinando Scavizzi
- EMMA CNR
- Marcello Raspa
- EMMA CNR
- Federico Marini
- NMR-Based Metabolomics Laboratory (NMLab), Sapienza University of Rome
- Alberta Tomassini
- Department of Chemistry, Sapienza University of Rome
- Roberta Nicolosi
- Department of Chemistry, Sapienza University of Rome
- Carolina Cason
- Department of Medical Sciences, University of Trieste
- Flavia Trettel
- Department of Physiology and Pharmacology, Sapienza University
- Alfredo Miccheli
- NMR-Based Metabolomics Laboratory (NMLab), Sapienza University of Rome
- Valerio Iebba
- Department of Medical Sciences, University of Trieste
- Giuseppina D’Alessandro
- Department of Physiology and Pharmacology, Sapienza University
- Cristina Limatola
- IRCCS Neuromed
- DOI
- https://doi.org/10.1038/s42003-022-03468-9
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 13
Abstract
Mice exposed to environmental enrichment for 5 weeks display distinct microbiota composition and behavioral and metabolic profiles compared to mice exposed to a standard environment. Mice treated with a mixture of short-chain fatty acids that are produced by gut bacteria recapitulate some of the effects of this environmental enrichment.
