Holmium Complex with Phospholipids as ¹H NMR Relaxational Sensor of Temperature and Viscosity

Abstract

The sensitivity of Ho–phospholipid complexes to changes in the membrane viscosity of liposomes was checked. An increase in viscosity was observed for DPPC and DMPC near the phase-transition temperature. Ho–phospholipid complexes could be used as sensors of local membrane viscosity in NMR and MRI technologies.

Keywords

• lanthanides
• lipid membrane
• NMR
• membrane viscosity sensor
• paramagnetic shift