Nature Communications (Feb 2021)
METTL3-dependent m6A modification programs T follicular helper cell differentiation
- Yingpeng Yao,
- Ying Yang,
- Wenhui Guo,
- Lifan Xu,
- Menghao You,
- Yi-Chang Zhang,
- Zhen Sun,
- Xiao Cui,
- Guotao Yu,
- Zhihong Qi,
- Jingjing Liu,
- Fang Wang,
- Juanjuan Liu,
- Tianyan Zhao,
- Lilin Ye,
- Yun-Gui Yang,
- Shuyang Yu
Affiliations
- Yingpeng Yao
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Ying Yang
- CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, CAS Center for Excellence in Molecular Cell Science, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences
- Wenhui Guo
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Lifan Xu
- Institute of Immunology, Third Military Medical University
- Menghao You
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Yi-Chang Zhang
- CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, CAS Center for Excellence in Molecular Cell Science, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences
- Zhen Sun
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Xiao Cui
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Guotao Yu
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Zhihong Qi
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Jingjing Liu
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Fang Wang
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Juanjuan Liu
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Tianyan Zhao
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Lilin Ye
- Institute of Immunology, Third Military Medical University
- Yun-Gui Yang
- CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, CAS Center for Excellence in Molecular Cell Science, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences
- Shuyang Yu
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- DOI
- https://doi.org/10.1038/s41467-021-21594-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
T follicular helper (TFH) cells are specialized effector CD4+ T cells that are critical in humoral immunity, but the function of post-transcriptional regulation is not clearly defined. Here, the authors demonstrate that RNA methylation is important for TFH effector differentiation and subsequent antibody formation through stabilization of Tcf7 transcripts.
