Nature Communications (Nov 2017)

Structural basis for tRNA-dependent cysteine biosynthesis

  • Meirong Chen,
  • Koji Kato,
  • Yume Kubo,
  • Yoshikazu Tanaka,
  • Yuchen Liu,
  • Feng Long,
  • William B. Whitman,
  • Pascal Lill,
  • Christos Gatsogiannis,
  • Stefan Raunser,
  • Nobutaka Shimizu,
  • Akira Shinoda,
  • Akiyoshi Nakamura,
  • Isao Tanaka,
  • Min Yao

DOI
https://doi.org/10.1038/s41467-017-01543-y
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 12

Abstract

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tRNA-dependent cysteine biosynthesis is catalyzed by the transsulfursome protein complex. Here, the authors use a multidisciplinary approach to structurally characterize the archaeal transsulfursome and propose a model for tRNA channeling in the complex.