Light-Addressable Potentiometric Sensor as a Sensing Element in Plug-Based Microfluidic Devices

Ko-Ichiro Miyamoto; Takuya Sato; Minami Abe; Torsten Wagner; Michael J. Schöning; Tatsuo Yoshinobu

doi:10.3390/mi7070111

Micromachines (Jul 2016)

Light-Addressable Potentiometric Sensor as a Sensing Element in Plug-Based Microfluidic Devices

Ko-Ichiro Miyamoto,
Takuya Sato,
Minami Abe,
Torsten Wagner,
Michael J. Schöning,
Tatsuo Yoshinobu

Affiliations

Ko-Ichiro Miyamoto: Department of Electronic Engineering, Tohoku University, 6-6-05 Aza-Aoba, Aramaki, Aoba-ku, Sendai 980-8579, Japan
Takuya Sato: Department of Electronic Engineering, Tohoku University, 6-6-05 Aza-Aoba, Aramaki, Aoba-ku, Sendai 980-8579, Japan
Minami Abe: Department of Electronic Engineering, Tohoku University, 6-6-05 Aza-Aoba, Aramaki, Aoba-ku, Sendai 980-8579, Japan
Torsten Wagner: Institute of Nano- and Biotechnologies, Aachen University of Applied Sciences, Heinrich-Mußmann-Str. 1, Jülich 52428, Germany
Michael J. Schöning: Institute of Nano- and Biotechnologies, Aachen University of Applied Sciences, Heinrich-Mußmann-Str. 1, Jülich 52428, Germany
Tatsuo Yoshinobu: Department of Electronic Engineering, Tohoku University, 6-6-05 Aza-Aoba, Aramaki, Aoba-ku, Sendai 980-8579, Japan

DOI: https://doi.org/10.3390/mi7070111
Journal volume & issue: Vol. 7, no. 7
p. 111

Abstract

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A plug-based microfluidic system based on the principle of the light-addressable potentiometric sensor (LAPS) is proposed. The LAPS is a semiconductor-based chemical sensor, which has a free addressability of the measurement point on the sensing surface. By combining a microfluidic device and LAPS, ion sensing can be performed anywhere inside the microfluidic channel. In this study, the sample solution to be measured was introduced into the channel in a form of a plug with a volume in the range of microliters. Taking advantage of the light-addressability, the position of the plug could be monitored and pneumatically controlled. With the developed system, the pH value of a plug with a volume down to 400 nL could be measured. As an example of plug-based operation, two plugs were merged in the channel, and the pH change was detected by differential measurement.

Published in Micromachines

ISSN: 2072-666X (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Technology: Mechanical engineering and machinery
Website: https://www.mdpi.com/journal/micromachines

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