Nature Communications (Dec 2020)
A single dose of recombinant VSV-∆G-spike vaccine provides protection against SARS-CoV-2 challenge
- Yfat Yahalom-Ronen,
- Hadas Tamir,
- Sharon Melamed,
- Boaz Politi,
- Ohad Shifman,
- Hagit Achdout,
- Einat B. Vitner,
- Ofir Israeli,
- Elad Milrot,
- Dana Stein,
- Inbar Cohen-Gihon,
- Shlomi Lazar,
- Hila Gutman,
- Itai Glinert,
- Lilach Cherry,
- Yaron Vagima,
- Shirley Lazar,
- Shay Weiss,
- Amir Ben-Shmuel,
- Roy Avraham,
- Reut Puni,
- Edith Lupu,
- Elad Bar-David,
- Assa Sittner,
- Noam Erez,
- Ran Zichel,
- Emanuelle Mamroud,
- Ohad Mazor,
- Haim Levy,
- Orly Laskar,
- Shmuel Yitzhaki,
- Shmuel C. Shapira,
- Anat Zvi,
- Adi Beth-Din,
- Nir Paran,
- Tomer Israely
Affiliations
- Yfat Yahalom-Ronen
- Israel Institute for Biological Research
- Hadas Tamir
- Israel Institute for Biological Research
- Sharon Melamed
- Israel Institute for Biological Research
- Boaz Politi
- Israel Institute for Biological Research
- Ohad Shifman
- Israel Institute for Biological Research
- Hagit Achdout
- Israel Institute for Biological Research
- Einat B. Vitner
- Israel Institute for Biological Research
- Ofir Israeli
- Israel Institute for Biological Research
- Elad Milrot
- Israel Institute for Biological Research
- Dana Stein
- Israel Institute for Biological Research
- Inbar Cohen-Gihon
- Israel Institute for Biological Research
- Shlomi Lazar
- Israel Institute for Biological Research
- Hila Gutman
- Israel Institute for Biological Research
- Itai Glinert
- Israel Institute for Biological Research
- Lilach Cherry
- Israel Institute for Biological Research
- Yaron Vagima
- Israel Institute for Biological Research
- Shirley Lazar
- Israel Institute for Biological Research
- Shay Weiss
- Israel Institute for Biological Research
- Amir Ben-Shmuel
- Israel Institute for Biological Research
- Roy Avraham
- Israel Institute for Biological Research
- Reut Puni
- Israel Institute for Biological Research
- Edith Lupu
- Israel Institute for Biological Research
- Elad Bar-David
- Israel Institute for Biological Research
- Assa Sittner
- Israel Institute for Biological Research
- Noam Erez
- Israel Institute for Biological Research
- Ran Zichel
- Israel Institute for Biological Research
- Emanuelle Mamroud
- Israel Institute for Biological Research
- Ohad Mazor
- Israel Institute for Biological Research
- Haim Levy
- Israel Institute for Biological Research
- Orly Laskar
- Israel Institute for Biological Research
- Shmuel Yitzhaki
- Israel Institute for Biological Research
- Shmuel C. Shapira
- Israel Institute for Biological Research
- Anat Zvi
- Israel Institute for Biological Research
- Adi Beth-Din
- Israel Institute for Biological Research
- Nir Paran
- Israel Institute for Biological Research
- Tomer Israely
- Israel Institute for Biological Research
- DOI
- https://doi.org/10.1038/s41467-020-20228-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
Here, the authors generate a replication-competent VSV based vaccine expressing SARS-CoV-2 spike protein and show protection in the hamster model with one dose. Analysis of the antibody response in mice shows induction of neutralizing antibodies and suggests a desirable Th1-biased response to the vaccine.
