Nature Communications (Jul 2022)
Upper airway gene expression shows a more robust adaptive immune response to SARS-CoV-2 in children
- Eran Mick,
- Alexandra Tsitsiklis,
- Natasha Spottiswoode,
- Saharai Caldera,
- Paula Hayakawa Serpa,
- Angela M. Detweiler,
- Norma Neff,
- Angela Oliveira Pisco,
- Lucy M. Li,
- Hanna Retallack,
- Kalani Ratnasiri,
- Kayla M. Williamson,
- Victoria Soesanto,
- Eric A. F. Simões,
- Christiana Smith,
- Lisa Abuogi,
- Amy Kistler,
- Brandie D. Wagner,
- Joseph L. DeRisi,
- Lilliam Ambroggio,
- Peter M. Mourani,
- Charles R. Langelier
Affiliations
- Eran Mick
- Division of Infectious Diseases, University of California
- Alexandra Tsitsiklis
- Division of Infectious Diseases, University of California
- Natasha Spottiswoode
- Division of Infectious Diseases, University of California
- Saharai Caldera
- Division of Infectious Diseases, University of California
- Paula Hayakawa Serpa
- Division of Infectious Diseases, University of California
- Angela M. Detweiler
- Chan Zuckerberg Biohub
- Norma Neff
- Chan Zuckerberg Biohub
- Angela Oliveira Pisco
- Chan Zuckerberg Biohub
- Lucy M. Li
- Chan Zuckerberg Biohub
- Hanna Retallack
- Department of Biochemistry and Biophysics, University of California
- Kalani Ratnasiri
- Chan Zuckerberg Biohub
- Kayla M. Williamson
- Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado
- Victoria Soesanto
- Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado
- Eric A. F. Simões
- Department of Pediatrics, University of Colorado and Children’s Hospital Colorado
- Christiana Smith
- Department of Pediatrics, University of Colorado and Children’s Hospital Colorado
- Lisa Abuogi
- Department of Pediatrics, University of Colorado and Children’s Hospital Colorado
- Amy Kistler
- Chan Zuckerberg Biohub
- Brandie D. Wagner
- Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado
- Joseph L. DeRisi
- Chan Zuckerberg Biohub
- Lilliam Ambroggio
- Department of Pediatrics, University of Colorado and Children’s Hospital Colorado
- Peter M. Mourani
- Department of Pediatrics, University of Colorado and Children’s Hospital Colorado
- Charles R. Langelier
- Division of Infectious Diseases, University of California
- DOI
- https://doi.org/10.1038/s41467-022-31600-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
The difference between children and adults in response to SARS-CoV-2 infection is not clearly established. Here the authors use gene expression analysis of nasopharyngeal samples from children and adults and show a higher level of immune response in children compared to adults, including of B and T cell activation.
