Nature Communications (Apr 2018)

A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel

  • Yanfeng Wang,
  • Shaopeng Chi,
  • Huifang Guo,
  • Guang Li,
  • Li Wang,
  • Qiancheng Zhao,
  • Yu Rao,
  • Liansuo Zu,
  • Wei He,
  • Bailong Xiao

DOI
https://doi.org/10.1038/s41467-018-03570-9
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

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Piezo1 is a large trimeric ion channel activated by mechanical stimulus. Here the authors identify chemical activators of Piezo1 that utilize a lever-like mechanotransduction pathway for long-range allosteric gating.