Toxin secretion and trafficking by Mycobacterium tuberculosis

David Pajuelo; Uday Tak; Lei Zhang; Olga Danilchanka; Anna D. Tischler; Michael Niederweis

doi:10.1038/s41467-021-26925-1

Nature Communications (Nov 2021)

Toxin secretion and trafficking by Mycobacterium tuberculosis

David Pajuelo,
Uday Tak,
Lei Zhang,
Olga Danilchanka,
Anna D. Tischler,
Michael Niederweis

Affiliations

David Pajuelo: Department of Microbiology, University of Alabama at Birmingham
Uday Tak: Department of Microbiology, University of Alabama at Birmingham
Lei Zhang: Department of Microbiology, University of Alabama at Birmingham
Olga Danilchanka: Department of Microbiology, University of Alabama at Birmingham
Anna D. Tischler: Department of Microbiology and Immunology, University of Minnesota Twin Cities
Michael Niederweis: Department of Microbiology, University of Alabama at Birmingham

DOI: https://doi.org/10.1038/s41467-021-26925-1
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

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The tuberculosis necrotizing toxin (TNT) is the major cytotoxicity factor of M. tuberculosis (Mtb). Mtb possesses five type VII secretion systems (ESX). Pajuelo et al. show that the ESX-4 system is required for TNT secretion and that ESX-2 and ESX-4 systems work in concert with ESX-1 to permeabilize the phagosomal membrane and enable trafficking of TNT into the cytoplasm of macrophages infected with Mtb.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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