Establishment of an induced pluripotent stem (iPS) cell line (SDUKIi006-A) from a 21-year old male patient diagnosed with atypical autism disorder

Morad Kamand; Sheena Louise Forsberg; Mads Thomassen; Mirolyuba Ilieva; Morten Meyer; Åsa Fex Svenningsen; Tanja Maria Michel

Stem Cell Research (Mar 2021)

Establishment of an induced pluripotent stem (iPS) cell line (SDUKIi006-A) from a 21-year old male patient diagnosed with atypical autism disorder

Morad Kamand,
Sheena Louise Forsberg,
Mads Thomassen,
Mirolyuba Ilieva,
Morten Meyer,
Åsa Fex Svenningsen,
Tanja Maria Michel

Affiliations

Morad Kamand: Department of Clinical Research, Department of Psychiatry, University of Southern Denmark, Odense, Denmark; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark; Psychiatry in the Region of Southern Denmark, Odense University Hospital, Denmark; Corresponding author at: Department of Clinical Research, Department of Psychiatry, University of Southern Denmark, Odense, Denmark.
Sheena Louise Forsberg: Department of Clinical Research, Department of Psychiatry, University of Southern Denmark, Odense, Denmark; Psychiatry in the Region of Southern Denmark, Odense University Hospital, Denmark
Mads Thomassen: Department of Clinical Research, Department of Human Genetics, Odense University Hospital, Denmark
Mirolyuba Ilieva: Department of Clinical Research, Department of Psychiatry, University of Southern Denmark, Odense, Denmark; Psychiatry in the Region of Southern Denmark, Odense University Hospital, Denmark
Morten Meyer: Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark; Brain Research – Inter Disciplinary Guided Excellence (BRIDGE), Odense, Denmark; Department of Neurology, Odense University Hospital, Denmark
Åsa Fex Svenningsen: Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark; Brain Research – Inter Disciplinary Guided Excellence (BRIDGE), Odense, Denmark
Tanja Maria Michel: Department of Clinical Research, Department of Psychiatry, University of Southern Denmark, Odense, Denmark; Brain Research – Inter Disciplinary Guided Excellence (BRIDGE), Odense, Denmark; Psychiatry in the Region of Southern Denmark, Odense University Hospital, Denmark

Journal volume & issue: Vol. 51
p. 102185

Abstract

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Autism is a complex neuropsychiatric disorder defined by significant challenges in communication skills and social behavior as well as repetitive conduct and interests. Recent advances in stem cell technologies allow in vitro modeling of the underlying molecular disease mechanisms. Using integration-free episomal plasmids, we have generated a novel iPS cell line (SDUKIi006-A) from a patient diagnosed with atypical autism (“FYNEN cohort” of Southern Denmark). Characterization of the established cell line validated its expression of pluripotency markers, differentiation into the three germ layers, and the absence of chromosomal abnormalities.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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