Molecular & Cellular Oncology (Jul 2021)

TFG: a novel regulator of ULK1-dependent autophagy

  • Francesco Cecconi,
  • Francesca Nazio

DOI
https://doi.org/10.1080/23723556.2021.1945895
Journal volume & issue
Vol. 8, no. 4

Abstract

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TRK-fused gene (TFG) is a protein implicated in multiple neurodegenerative diseases and oncogenesis. We have recently shown that, under starvation conditions, TFG contributes to spatial control of autophagy by facilitating Unc-51 like autophagy activating kinase 1 (ULK1)-microtubule-associated protein 1 light chain 3 gamma (MAP1LC3C) interaction to modulate omegasome and autophagosome formation. Defective TFG-mediated autophagy could thus be postulated as a possible contributor to ontogenesis or progression of TFG-related diseases.

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