Genome Sequence and Attenuating Mutations in West Nile Virus Isolate from Mexico

Abstract

The complete genome sequence of a Mexican West Nile virus isolate, TM171-03, included 46 nucleotide (0.42%) and 4 amino acid (0.11%) differences from the NY99 prototype. Mouse virulence differences between plaque-purified variants of TM171-03 with mutations at the E protein glycosylation motif suggest the emergence of an attenuating mutation.

Keywords

• West Nile virus
• arbovirus
• flavivirus
• Mexico
• genome sequence
• dispatch