Jichu yixue yu linchuang (May 2021)
Research progress on the role of ADAM17 in the pathogenesis of atherosclerosis
Abstract
Atherosclerosis is a kind of chronic inflammatory disease involving imbalance of lipid metabolism and immune disorders. The disintegrin metalloprotease 17(ADAM17) is a classic membrane protein shedding enzyme, which promotes atherosclerosis by participating in the process of inflammatory response, angiogenesis and plaque instability. In a few cases, ADAM17 also exhibits anti-atherosclerotic effects. Therefore, paying attention to the mechanism of ADAM17 in atherosclerosis will help to provide new insights into the diagnosis and treatment of atherosclerosis.
