The role of serum lactate and enzymes in predicting perinatal asphyxia

Abstract

Background: Perinatal asphyxia is a deficiency of blood flowing or gas exchanging to or from the fetusin the timejust earlier, during, or afterward the labour processes. Perinatal asphyxia could result in profound systemic andneurologic sequelae owingtoreducedblood flowing and/or oxygen to a fetus or infant throughout the peripartumtime. Objectives: the aim of the study was toevaluate the role of serum lactate and enzymes in predicting perinatal asphyxia. Patients and methods: the current work was a cross-sectional study performed at Qena University Hospital including 30 cases and 30 controls included of asphyxiated and non-asphyxiated babies respectively. Results: There was a statistically significant change (p < 0.001) among groups regarding levels of serum lactate, lactate dehydrogenase (LDH),creatine kinase muscle-brain fraction (CK-MB),aspartate aminotransferase (AST), and alanine aminotransferase(ALT). Conclusion:Perinatal asphyxia is a fundamental driver of neonatal death and long haul neurological harm still without prescient diagnostics, preventive as well as treatment of agreement.Estimation of lactate,CK-MB,LDH,AST, and ALTcould be utilized as a biomarker for diagnosing of perinatal asphyxia.

Keywords

• blood flow; fetus; marker; perinatal asphyxia; peripartum; serum enzymes