Targeting cancer’s sweet spot: UGP2 as a therapeutic vulnerability

Abstract

Understanding the mechanisms governing metabolic reprogramming that underlie potential vulnerabilities in cancer cells is key to developing novel therapeutic strategies. The catalytic enzyme UDP-glucose pyrophosphorylase 2 (UGP2) drives the production of UDP-glucose. Our recent work demonstrated the crucial role of UGP2 in cancer growth and its regulation of cellular metabolic processes.

Keywords

• ugp2
• udp-glucose
• yap
• cancer metabolism
• glycosylation