Factors Influencing the In Vitro Maturation (IVM) of Human Oocyte

Huixia Yang; Thomas Kolben; Sarah Meister; Corinna Paul; Julia van Dorp; Sibel Eren; Christina Kuhn; Martina Rahmeh; Sven Mahner; Udo Jeschke; Viktoria von Schönfeldt

doi:10.3390/biomedicines9121904

Biomedicines (Dec 2021)

Factors Influencing the In Vitro Maturation (IVM) of Human Oocyte

Huixia Yang,
Thomas Kolben,
Sarah Meister,
Corinna Paul,
Julia van Dorp,
Sibel Eren,
Christina Kuhn,
Martina Rahmeh,
Sven Mahner,
Udo Jeschke,
Viktoria von Schönfeldt

Affiliations

Huixia Yang: Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University, 81377 Munich, Germany
Thomas Kolben: Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University, 81377 Munich, Germany
Sarah Meister: Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University, 81377 Munich, Germany
Corinna Paul: Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University, 81377 Munich, Germany
Julia van Dorp: Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University, 81377 Munich, Germany
Sibel Eren: Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University, 81377 Munich, Germany
Christina Kuhn: Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University, 81377 Munich, Germany
Martina Rahmeh: Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University, 81377 Munich, Germany
Sven Mahner: Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University, 81377 Munich, Germany
Udo Jeschke: Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University, 81377 Munich, Germany
Viktoria von Schönfeldt: Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University, 81377 Munich, Germany

DOI: https://doi.org/10.3390/biomedicines9121904
Journal volume & issue: Vol. 9, no. 12
p. 1904

Abstract

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In vitro maturation (IVM) of oocytes is a promising assisted reproductive technology (ART) deemed as a simple and safe procedure. It is mainly used in patients with impaired oocyte maturation and in fertility preservation for women facing the risk of losing fertility. However, to date, it is still not widely used in clinical practice because of its underperformance. The influencing factors, such as biphasic IVM system, culture medium, and the supplementation, have a marked effect on the outcomes of oocyte IVM. However, the role of different culture media, supplements, and follicular priming regimens in oocyte IVM have yet to be fully clarified and deserve further investigation.

Published in Biomedicines

ISSN: 2227-9059 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: http://www.mdpi.com/journal/biomedicines

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