Nature Communications (May 2017)
Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen
- Celia Miguel-Blanco,
- Irene Molina,
- Ana I. Bardera,
- Beatriz Díaz,
- Laura de las Heras,
- Sonia Lozano,
- Carolina González,
- Janneth Rodrigues,
- Michael J. Delves,
- Andrea Ruecker,
- Gonzalo Colmenarejo,
- Sara Viera,
- María S. Martínez-Martínez,
- Esther Fernández,
- Jake Baum,
- Robert E. Sinden,
- Esperanza Herreros
Affiliations
- Celia Miguel-Blanco
- Diseases of the Developing World (DDW), GlaxoSmithKline
- Irene Molina
- Diseases of the Developing World (DDW), GlaxoSmithKline
- Ana I. Bardera
- Molecular Discovery Research (MDR), GlaxoSmithKline
- Beatriz Díaz
- Diseases of the Developing World (DDW), GlaxoSmithKline
- Laura de las Heras
- Diseases of the Developing World (DDW), GlaxoSmithKline
- Sonia Lozano
- Diseases of the Developing World (DDW), GlaxoSmithKline
- Carolina González
- Diseases of the Developing World (DDW), GlaxoSmithKline
- Janneth Rodrigues
- Diseases of the Developing World (DDW), GlaxoSmithKline
- Michael J. Delves
- Department of Life Sciences, Imperial College of London
- Andrea Ruecker
- Department of Life Sciences, Imperial College of London
- Gonzalo Colmenarejo
- Molecular Discovery Research (MDR), GlaxoSmithKline
- Sara Viera
- Diseases of the Developing World (DDW), GlaxoSmithKline
- María S. Martínez-Martínez
- Diseases of the Developing World (DDW), GlaxoSmithKline
- Esther Fernández
- Diseases of the Developing World (DDW), GlaxoSmithKline
- Jake Baum
- Department of Life Sciences, Imperial College of London
- Robert E. Sinden
- Department of Life Sciences, Imperial College of London
- Esperanza Herreros
- Diseases of the Developing World (DDW), GlaxoSmithKline
- DOI
- https://doi.org/10.1038/ncomms15160
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 10
Abstract
There is a need forPlasmodium transmission blocking drugs for malaria elimination. Here, Miguel-Blanco et al. screen >10,000 compounds against stage V female gametocytes, identify active compounds belonging to 57 chemotypes and confirm transmission blocking activity of four selected compounds in vitro.
