Nature Communications (Oct 2017)
MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists
- Cong Lv,
- Fengyin Li,
- Xiang Li,
- Yuhua Tian,
- Yue Zhang,
- Xiaole Sheng,
- Yongli Song,
- Qingyong Meng,
- Shukai Yuan,
- Liming Luan,
- Thomas Andl,
- Xu Feng,
- Baowei Jiao,
- Mingang Xu,
- Maksim V. Plikus,
- Xing Dai,
- Christopher Lengner,
- Wei Cui,
- Fazheng Ren,
- Jianwei Shuai,
- Sarah E. Millar,
- Zhengquan Yu
Affiliations
- Cong Lv
- State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University
- Fengyin Li
- State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University
- Xiang Li
- State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University
- Yuhua Tian
- State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University
- Yue Zhang
- Department of Biochemistry and Molecular Biology, Hebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Disease, Hebei University of Chinese Medicine
- Xiaole Sheng
- State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University
- Yongli Song
- State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University
- Qingyong Meng
- State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University
- Shukai Yuan
- Department of Biochemistry and Molecular Biology, Basic Medical College, Tianjin Medical University
- Liming Luan
- Vanderbilt University Medical Center
- Thomas Andl
- Vanderbilt University Medical Center
- Xu Feng
- State Key Laboratory of Genetic Resources and Evolution of Kunming Institute of Zoology, Chinese Academy of Sciences
- Baowei Jiao
- State Key Laboratory of Genetic Resources and Evolution of Kunming Institute of Zoology, Chinese Academy of Sciences
- Mingang Xu
- Department of Dermatology, Perelman School of Medicine, University of Pennsylvania
- Maksim V. Plikus
- Department of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research, Center for Complex Biological Systems, University of California, Irvine
- Xing Dai
- Departments of Biological Chemistry and Dermatology, School of Medicine, University of California
- Christopher Lengner
- Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania
- Wei Cui
- State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University
- Fazheng Ren
- State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University
- Jianwei Shuai
- Department of Physics and State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, Xiamen University
- Sarah E. Millar
- Department of Dermatology, Perelman School of Medicine, University of Pennsylvania
- Zhengquan Yu
- State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University
- DOI
- https://doi.org/10.1038/s41467-017-01059-5
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 18
Abstract
MicroRNAs play an important role in stem cell fate and tumorigenesis. In this work, the authors show that miR-31 controls mammary stem cell self-renewal and tumorigenesis by simultaneously activating Wnt/β-catenin and repressing TGFβ signaling pathways.
