Human stem cells harboring a suicide gene improve the safety and standardisation of neural transplants in Parkinsonian rats

Isabelle R. de Luzy; Kevin C. L. Law; Niamh Moriarty; Cameron P. J. Hunt; Jennifer C. Durnall; Lachlan H. Thompson; Andras Nagy; Clare L. Parish

doi:10.1038/s41467-021-23125-9

Nature Communications (May 2021)

Human stem cells harboring a suicide gene improve the safety and standardisation of neural transplants in Parkinsonian rats

Isabelle R. de Luzy,
Kevin C. L. Law,
Niamh Moriarty,
Cameron P. J. Hunt,
Jennifer C. Durnall,
Lachlan H. Thompson,
Andras Nagy,
Clare L. Parish

Affiliations

Isabelle R. de Luzy: The Florey Institute of Neuroscience and Mental Health, The University of Melbourne
Kevin C. L. Law: The Florey Institute of Neuroscience and Mental Health, The University of Melbourne
Niamh Moriarty: The Florey Institute of Neuroscience and Mental Health, The University of Melbourne
Cameron P. J. Hunt: The Florey Institute of Neuroscience and Mental Health, The University of Melbourne
Jennifer C. Durnall: The Florey Institute of Neuroscience and Mental Health, The University of Melbourne
Lachlan H. Thompson: The Florey Institute of Neuroscience and Mental Health, The University of Melbourne
Andras Nagy: Australian Regenerative Medicine Institute, Monash University
Clare L. Parish: The Florey Institute of Neuroscience and Mental Health, The University of Melbourne

DOI: https://doi.org/10.1038/s41467-021-23125-9
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 11

Abstract

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Stem cell grafts present a risk of tissue overgrowth/tumors. Here, the authors utilise a human pluripotent stem cell line carrying a FailSafe suicide gene to not only ablate proliferative cells, but through timely gene activation, improve the purity of neural grafts in Parkinsonian rats.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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