808 nm Near-Infrared Light-Excited UCNPs@mSiO2-Ce6-GPC3 Nanocomposites For Photodynamic Therapy In Liver Cancer

Abstract

Jiahe Hu,1,* Jialan Shi,2,3 Yingqian Gao,1 Wei Yang,1 Ping Liu,1 Qinghao Liu,1 Fei He,4 Chunxu Wang,2 Tao Li,2 Rui Xie,1 Jiuxin Zhu,5 Piaoping Yang4,* 1Department of Digestive Internal Medicine, Harbin Medical University Cancer Hospital, Harbin 150081, People’s Republic of China; 2Department of Hematology, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, People’s Republic of China; 3Department of Surgery, VA Boston Healthcare System, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 12132, USA; 4Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, People’s Republic of China; 5Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratories of Cardiovascular Medicine Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin 150081, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jiuxin ZhuDepartment of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China Key Laboratories of Cardiovascular Medicine Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin 150081, People’s Republic of ChinaTel [phone]Email [email protected] XieDepartment of Digestive Internal Medicine Harbin Medical University Cancer Hospital, 150 Haping Road, Nangang District, Heilongjiang, Harbin 150081, People’s Republic of ChinaTel [phone]Email [email protected]: It is important to explore effective treatment for liver cancer. Photodynamic therapy (PDT) is a novel technique to treat liver cancer, but its clinical application is obstructed by limited depth of visible light penetration into tissue. The near-infrared (NIR) photosensitizer is a potential solution to the limitations of PDT for deep tumor tissue treatment.Purpose: We aimed to investigate 808 nm NIR light-excited UCNPs@mSiO2-Ce6-GPC3 nanocomposites for PDT in liver cancer.Methods: In our study, 808 nm NIR light-excited upconversion nanoparticles (UCNPs) were simultaneously loaded with the photosensitizer chlorin e6 (Ce6) and the antibody glypican-3 (GPC3), which is overexpressed in hepatocellular carcinoma cells. The multitasking UCNPs@mSiO2-Ce6-GPC3 nanoparticles under 808 nm laser irradiation with enhanced depth of penetration would enable the effective targeting of PDT.Results: We found that the UCNPs@mSiO2-Ce6-GPC3 nanoparticles had good biocompatibility, low toxicity, excellent cell imaging in HepG2 cancer cells and high anti-tumor effect in vitro and in vivo.Conclusion: We believe that the utilization of 808 nm NIR excited UCNPs@mSiO2-Ce6-GPC3 nanoparticles for PDT is a safe and potential therapeutic option for liver cancer.Keywords: liver cancer, photodynamic therapy, upconversion nanoparticles, 808 nm NIR, GPC3, targeted therapy

Keywords

• liver cancer
• photodynamic therapy
• upconversion nanoparticles
• 808 nm nir
• gpc3
• targeted therapy