Nature Communications (Apr 2022)
Integrative analysis of non-small cell lung cancer patient-derived xenografts identifies distinct proteotypes associated with patient outcomes
- Shideh Mirhadi,
- Shirley Tam,
- Quan Li,
- Nadeem Moghal,
- Nhu-An Pham,
- Jiefei Tong,
- Brian J. Golbourn,
- Jonathan R. Krieger,
- Paul Taylor,
- Ming Li,
- Jessica Weiss,
- Sebastiao N. Martins-Filho,
- Vibha Raghavan,
- Yasin Mamatjan,
- Aafaque A. Khan,
- Michael Cabanero,
- Shingo Sakashita,
- Kugeng Huo,
- Sameer Agnihotri,
- Kota Ishizawa,
- Thomas K. Waddell,
- Gelareh Zadeh,
- Kazuhiro Yasufuku,
- Geoffrey Liu,
- Frances A. Shepherd,
- Michael F. Moran,
- Ming-Sound Tsao
Affiliations
- Shideh Mirhadi
- Program in Cell Biology, Hospital for Sick Children
- Shirley Tam
- Princess Margaret Cancer Centre, University Health Network
- Quan Li
- Princess Margaret Cancer Centre, University Health Network
- Nadeem Moghal
- Princess Margaret Cancer Centre, University Health Network
- Nhu-An Pham
- Princess Margaret Cancer Centre, University Health Network
- Jiefei Tong
- Program in Cell Biology, Hospital for Sick Children
- Brian J. Golbourn
- John G. Rangos Sr. Research Center, Children’s Hospital of Pittsburgh, and Department of Neurological Surgery, University of Pittsburgh School of Medicine
- Jonathan R. Krieger
- SPARC BioCentre, Hospital for Sick Children
- Paul Taylor
- Program in Cell Biology, Hospital for Sick Children
- Ming Li
- Princess Margaret Cancer Centre, University Health Network
- Jessica Weiss
- Department of Biostatistics, Princess Margaret Cancer Centre
- Sebastiao N. Martins-Filho
- Princess Margaret Cancer Centre, University Health Network
- Vibha Raghavan
- Princess Margaret Cancer Centre, University Health Network
- Yasin Mamatjan
- Princess Margaret Cancer Centre, University Health Network
- Aafaque A. Khan
- Program in Cell Biology, Hospital for Sick Children
- Michael Cabanero
- Princess Margaret Cancer Centre, University Health Network
- Shingo Sakashita
- Princess Margaret Cancer Centre, University Health Network
- Kugeng Huo
- Princess Margaret Cancer Centre, University Health Network
- Sameer Agnihotri
- John G. Rangos Sr. Research Center, Children’s Hospital of Pittsburgh, and Department of Neurological Surgery, University of Pittsburgh School of Medicine
- Kota Ishizawa
- Division of Thoracic Surgery, Toronto General Hospital, University Health Network
- Thomas K. Waddell
- Division of Thoracic Surgery, Toronto General Hospital, University Health Network
- Gelareh Zadeh
- Princess Margaret Cancer Centre, University Health Network
- Kazuhiro Yasufuku
- Division of Thoracic Surgery, Toronto General Hospital, University Health Network
- Geoffrey Liu
- Princess Margaret Cancer Centre, University Health Network
- Frances A. Shepherd
- Princess Margaret Cancer Centre, University Health Network
- Michael F. Moran
- Program in Cell Biology, Hospital for Sick Children
- Ming-Sound Tsao
- Princess Margaret Cancer Centre, University Health Network
- DOI
- https://doi.org/10.1038/s41467-022-29444-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
With non-small cell lung cancer (NSCLC) being the leading cause of cancer deaths worldwide, the development of targeted therapies remains crucial. Here, the generation and multi-omics characterization of 137 NSCLC patient-derived xenografts provides a resource for potential classifications and targets.
