Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5

Jinuk Kong; Yul Ji; Yong Geun Jeon; Ji Seul Han; Kyung Hee Han; Jung Hyun Lee; Gung Lee; Hagoon Jang; Sung Sik Choe; Myriam Baes; Jae Bum Kim

doi:10.1038/s41467-019-14176-0

Nature Communications (Jan 2020)

Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5

Jinuk Kong,
Yul Ji,
Yong Geun Jeon,
Ji Seul Han,
Kyung Hee Han,
Jung Hyun Lee,
Gung Lee,
Hagoon Jang,
Sung Sik Choe,
Myriam Baes,
Jae Bum Kim

Affiliations

Jinuk Kong: National Creative Research Initiatives Center for Adipose Tissue Remodeling, Institute of Molecular Biology and Genetics, Department of Biological Sciences, Seoul National University
Yul Ji: National Creative Research Initiatives Center for Adipose Tissue Remodeling, Institute of Molecular Biology and Genetics, Department of Biological Sciences, Seoul National University
Yong Geun Jeon: National Creative Research Initiatives Center for Adipose Tissue Remodeling, Institute of Molecular Biology and Genetics, Department of Biological Sciences, Seoul National University
Ji Seul Han: National Creative Research Initiatives Center for Adipose Tissue Remodeling, Institute of Molecular Biology and Genetics, Department of Biological Sciences, Seoul National University
Kyung Hee Han: National Creative Research Initiatives Center for Adipose Tissue Remodeling, Institute of Molecular Biology and Genetics, Department of Biological Sciences, Seoul National University
Jung Hyun Lee: National Creative Research Initiatives Center for Adipose Tissue Remodeling, Institute of Molecular Biology and Genetics, Department of Biological Sciences, Seoul National University
Gung Lee: National Creative Research Initiatives Center for Adipose Tissue Remodeling, Institute of Molecular Biology and Genetics, Department of Biological Sciences, Seoul National University
Hagoon Jang: National Creative Research Initiatives Center for Adipose Tissue Remodeling, Institute of Molecular Biology and Genetics, Department of Biological Sciences, Seoul National University
Sung Sik Choe: National Creative Research Initiatives Center for Adipose Tissue Remodeling, Institute of Molecular Biology and Genetics, Department of Biological Sciences, Seoul National University
Myriam Baes: Laboratory of Cell Metabolism, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven
Jae Bum Kim: National Creative Research Initiatives Center for Adipose Tissue Remodeling, Institute of Molecular Biology and Genetics, Department of Biological Sciences, Seoul National University

DOI: https://doi.org/10.1038/s41467-019-14176-0
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 16

Abstract

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Lipid droplets are organelles that regulate lipid metabolism but if organellar contacts play a role during lipolysis is unclear. Here, the authors show that peroxisomes and peroxisomal protein PEX5 play pivotal roles in the spatial and temporal regulation of fasting-induced lipolysis by translocating ATGL onto lipid droplets

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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