Nature Communications (Aug 2020)

Surveillance of cohesin-supported chromosome structure controls meiotic progression

  • Maikel Castellano-Pozo,
  • Sarai Pacheco,
  • Georgios Sioutas,
  • Angel Luis Jaso-Tamame,
  • Marian H. Dore,
  • Mohammad M. Karimi,
  • Enrique Martinez-Perez

DOI
https://doi.org/10.1038/s41467-020-18219-9
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

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Meiosis-specific cohesins and the synaptonemal complex are essential for meiotic chromosome structure and function. Here the authors show that continued surveillance of these chromosome structures controls meiotic progression by regulating CHK-2, a master regulator of pairing and recombination.