Communications Chemistry (Nov 2022)

Design, development and applications of copper-catalyzed regioselective (4 + 2) annulations between diaryliodonium salts and alkynes

  • Weilin Wang,
  • Junrui Zhou,
  • Chao Wang,
  • Congdi Zhang,
  • Xiao-Qian Zhang,
  • Youliang Wang

DOI
https://doi.org/10.1038/s42004-022-00768-3
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 7

Abstract

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Intermolecular (4 + 2) cycloaddition with alkynes is a powerful approach to construct isocoumarin moieties, however, regioselectivity remains challenging for the transition metal-catalyzed approach. Here, the authors report copper-catalyzed regioselective (4 + 2) annulations between diaryliodonium salts and alkynes to synthesize isocoumarin-type natural products.