Frontiers in Medicine (Aug 2021)
Recent Progress in Lyme Disease and Remaining Challenges
- Jason R. Bobe,
- Brandon L. Jutras,
- Elizabeth J. Horn,
- Monica E. Embers,
- Allison Bailey,
- Robert L. Moritz,
- Ying Zhang,
- Mark J. Soloski,
- Richard S. Ostfeld,
- Richard T. Marconi,
- John Aucott,
- Avi Ma'ayan,
- Felicia Keesing,
- Kim Lewis,
- Choukri Ben Mamoun,
- Alison W. Rebman,
- Mecaila E. McClune,
- Edward B. Breitschwerdt,
- Panga Jaipal Reddy,
- Ricardo Maggi,
- Frank Yang,
- Bennett Nemser,
- Aydogan Ozcan,
- Omai Garner,
- Dino Di Carlo,
- Zachary Ballard,
- Hyou-Arm Joung,
- Albert Garcia-Romeu,
- Roland R. Griffiths,
- Nicole Baumgarth,
- Brian A. Fallon
Affiliations
- Jason R. Bobe
- Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Brandon L. Jutras
- Department of Biochemistry, Fralin Life Sciences Institute, Virginia Tech, Blacksburg, VA, United States
- Elizabeth J. Horn
- Lyme Disease Biobank, Portland, OR, United States
- Monica E. Embers
- Tulane University Health Sciences, New Orleans, LA, United States
- Allison Bailey
- Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Robert L. Moritz
- Institute for Systems Biology, Seattle, WA, United States
- Ying Zhang
- State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Mark J. Soloski
- Division of Rheumatology, Department of Medicine, Lyme Disease Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States
- Richard S. Ostfeld
- Cary Institute of Ecosystem Studies, Millbrook, NY, United States
- Richard T. Marconi
- Department of Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, VA, United States
- John Aucott
- Division of Rheumatology, Department of Medicine, Lyme Disease Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States
- Avi Ma'ayan
- Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Felicia Keesing
- 0Bard College, Annandale, NY, United States
- Kim Lewis
- 1Department of Biology, Northeastern University, Boston, MA, United States
- Choukri Ben Mamoun
- 2Yale University School of Medicine, New Haven, CT, United States
- Alison W. Rebman
- Division of Rheumatology, Department of Medicine, Lyme Disease Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States
- Mecaila E. McClune
- Department of Biochemistry, Fralin Life Sciences Institute, Virginia Tech, Blacksburg, VA, United States
- Edward B. Breitschwerdt
- 3Department of Clinical Sciences, Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, United States
- Panga Jaipal Reddy
- Institute for Systems Biology, Seattle, WA, United States
- Ricardo Maggi
- 3Department of Clinical Sciences, Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, United States
- Frank Yang
- 4Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, United States
- Bennett Nemser
- 5Steven & Alexandra Cohen Foundation, Stamford, CT, United States
- Aydogan Ozcan
- 6University of California, Los Angeles, Los Angeles, CA, United States
- Omai Garner
- 6University of California, Los Angeles, Los Angeles, CA, United States
- Dino Di Carlo
- 6University of California, Los Angeles, Los Angeles, CA, United States
- Zachary Ballard
- 6University of California, Los Angeles, Los Angeles, CA, United States
- Hyou-Arm Joung
- 6University of California, Los Angeles, Los Angeles, CA, United States
- Albert Garcia-Romeu
- 7Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States
- Roland R. Griffiths
- 7Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States
- Nicole Baumgarth
- 8Center for Immunology and Infectious Diseases and the Department of Pathology, Microbiology & Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA, United States
- Brian A. Fallon
- 9Columbia University Irving Medical Center, New York, NY, United States
- DOI
- https://doi.org/10.3389/fmed.2021.666554
- Journal volume & issue
-
Vol. 8
Abstract
Lyme disease (also known as Lyme borreliosis) is the most common vector-borne disease in the United States with an estimated 476,000 cases per year. While historically, the long-term impact of Lyme disease on patients has been controversial, mounting evidence supports the idea that a substantial number of patients experience persistent symptoms following treatment. The research community has largely lacked the necessary funding to properly advance the scientific and clinical understanding of the disease, or to develop and evaluate innovative approaches for prevention, diagnosis, and treatment. Given the many outstanding questions raised into the diagnosis, clinical presentation and treatment of Lyme disease, and the underlying molecular mechanisms that trigger persistent disease, there is an urgent need for more support. This review article summarizes progress over the past 5 years in our understanding of Lyme and tick-borne diseases in the United States and highlights remaining challenges.
Keywords
