Mechanism of action of egfs in peri-implant physiology

Abstract

Objective: to understand the action of EGF on peri-implant behavior and what are the consequences of such interaction with the changes occurring in the prosthetic components of implant-supported dentures. Material and Methods: a search was done in the indexers OldMedline and Medline database, between 1980 and 2017, with the following terms in English: epidermal growth factor, osseointegration, and bone resorption. For the national literature, the indexer BBO was used. Likewise, the terms epidermal growth factor, osseointegration and bone resorption were investigated, in the same period. Results: recently, in terms of science, it has been found that EGFs have a role in maintaining biological distances also in peri-implant tissues. The cervical bone resorption, known as saucerization, which causes lowering of the level of the alveolar ridge is caused by the approach of the stratified squamous epithelium of the buccal mucosa, after the surgical act, to the underlying bone. Conclusion: the EGF mediator interacts with the receptors forming the peri-implant junctional epithelium, whose conformation approximates the bone, accelerating the resorption and provoking the saucerization. Changes in prosthetic components have been constant to fit the peri-implant behavior.

Keywords

• fator de crescimento epidérmico
• osseointegração
• reabsorção óssea.