Nature Communications (May 2018)
Top-down descending facilitation of spinal sensory excitatory transmission from the anterior cingulate cortex
- Tao Chen,
- Wataru Taniguchi,
- Qi-Yu Chen,
- Hidetoshi Tozaki-Saitoh,
- Qian Song,
- Ren-Hao Liu,
- Kohei Koga,
- Tsuyoshi Matsuda,
- Yae Kaito-Sugimura,
- Jian Wang,
- Zhi-Hua Li,
- Ya-Cheng Lu,
- Kazuhide Inoue,
- Makoto Tsuda,
- Yun-Qing Li,
- Terumasa Nakatsuka,
- Min Zhuo
Affiliations
- Tao Chen
- Center for Neuron and Disease, Frontier Institute of Science and Technology, Xi’an Jiaotong University
- Wataru Taniguchi
- Pain Research Center, Kansai University of Health Sciences, Kumatori
- Qi-Yu Chen
- Center for Neuron and Disease, Frontier Institute of Science and Technology, Xi’an Jiaotong University
- Hidetoshi Tozaki-Saitoh
- Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University
- Qian Song
- Center for Neuron and Disease, Frontier Institute of Science and Technology, Xi’an Jiaotong University
- Ren-Hao Liu
- Center for Neuron and Disease, Frontier Institute of Science and Technology, Xi’an Jiaotong University
- Kohei Koga
- Center for Neuron and Disease, Frontier Institute of Science and Technology, Xi’an Jiaotong University
- Tsuyoshi Matsuda
- Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University
- Yae Kaito-Sugimura
- Pain Research Center, Kansai University of Health Sciences, Kumatori
- Jian Wang
- Department of Anatomy, Histology and Embryology and K.K. Leung Brain Research Centre, The Fourth Military Medical University
- Zhi-Hua Li
- Department of Anatomy, Histology and Embryology and K.K. Leung Brain Research Centre, The Fourth Military Medical University
- Ya-Cheng Lu
- Department of Anatomy, Histology and Embryology and K.K. Leung Brain Research Centre, The Fourth Military Medical University
- Kazuhide Inoue
- Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University
- Makoto Tsuda
- Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University
- Yun-Qing Li
- Department of Anatomy, Histology and Embryology and K.K. Leung Brain Research Centre, The Fourth Military Medical University
- Terumasa Nakatsuka
- Pain Research Center, Kansai University of Health Sciences, Kumatori
- Min Zhuo
- Center for Neuron and Disease, Frontier Institute of Science and Technology, Xi’an Jiaotong University
- DOI
- https://doi.org/10.1038/s41467-018-04309-2
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 17
Abstract
It is known that descending facilitation of spinal responses may contribute to chronic pain, however many studies have focussed on brainstem mechanisms. Here the authors show that stimulation of the anterior cingulate cortex increases excitatory transmission in the dorsal horn, and that this may be via a direct pathway independent of the brainstem.
