HGF/R-spondin1 rescues liver dysfunction through the induction of Lgr5+ liver stem cells

Yuan Lin; Zhe-Ping Fang; Hong-Juan Liu; Li-Jing Wang; Zhiqiang Cheng; Na Tang; Tingting Li; Tengfei Liu; Hai-Xiong Han; Guangwen Cao; Li Liang; Yan-Qing Ding; Wei-Jie Zhou

doi:10.1038/s41467-017-01341-6

Nature Communications (Oct 2017)

HGF/R-spondin1 rescues liver dysfunction through the induction of Lgr5+ liver stem cells

Yuan Lin,
Zhe-Ping Fang,
Hong-Juan Liu,
Li-Jing Wang,
Zhiqiang Cheng,
Na Tang,
Tingting Li,
Tengfei Liu,
Hai-Xiong Han,
Guangwen Cao,
Li Liang,
Yan-Qing Ding,
Wei-Jie Zhou

Affiliations

Yuan Lin: Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou
Zhe-Ping Fang: Department of Hepatobiliary Surgery, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University
Hong-Juan Liu: Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University
Li-Jing Wang: Vascular Biology Research Institute, Basic Course of School, Guangdong Pharmaceutical University
Zhiqiang Cheng: Department of Pathology, Shenzhen People’s Hospital
Na Tang: Department of Pathology, Shenzhen People’s Hospital
Tingting Li: Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou
Tengfei Liu: Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou
Hai-Xiong Han: Department of Hepatobiliary Surgery, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University
Guangwen Cao: Department of Epidemiology, Second Military Medical University
Li Liang: Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou
Yan-Qing Ding: Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou
Wei-Jie Zhou: Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou

DOI: https://doi.org/10.1038/s41467-017-01341-6
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

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Organ regeneration by transplantation of ESC/iPSC-derived tissues is a promising but still challenging approach. Here Lin et al. show that liver damage caused by a chemical insult induces not only fibrosis but also Lgr5+ cell expansion that can be further promoted by treatment with HGF/R-spondin1.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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