Intensive blood pressure control in isolated systolic hypertension: a post hoc analysis of a cluster randomized trialResearch in context

Abstract

Summary: Background: The isolated systolic hypertension (ISH) is of high prevalence, with a relatively poor prognosis. However, there is still no direct evidence to demonstrate the benefits of intensive blood pressure (BP) control among these patients. We aimed to evaluate intensive BP control with the target of 0.05 for all interaction test). The incidences of symptomatic hypotension, syncope injurious falls and renal outcomes did not differ between the two groups, even though hypotension was increased in intervention group (RR:1.71; 95% CI: 1.28–2.28; P < 0.001). Interpretation: Intensive BP control (<130/80 mmHg) was effective and safe in patients with ISH for the prevention of CVD events. Funding: The Ministry of Science and Technology (China) of China and the Science and Technology Program of Liaoning Province, China.

Keywords

• Isolated systolic hypertension
• Intensive blood pressure control
• Cardiovascular disease