EClinicalMedicine (Nov 2022)
Virus kinetics and biochemical derangements among children with Ebolavirus disease
- Lindsey Kjaldgaard,
- Kasereka Masumbuko Claude,
- Daniel Mukadi-Bamuleka,
- Richard Kitenge-Omasumbu,
- Devika Dixit,
- François Edidi-Atani,
- Meris Matondo Kuamfumu,
- Junior Bulabula-Penge,
- Fabrice Mambu-Mbika,
- Olivier Tshiani-Mbaya,
- Janet Diaz,
- Sabue Mulangu,
- Anais Legand,
- Placide Mbala-Kingebeni,
- Pierre Formenty,
- Steve Ahuka-Mundeke,
- Jean-Jacques Muyembe-Tamfum,
- Michael T. Hawkes
Affiliations
- Lindsey Kjaldgaard
- Department of Paediatrics, University of Alberta, Edmonton, AB, Canada; Member, Women and Children's Research Institute, University of Alberta, Edmonton, AB, Canada
- Kasereka Masumbuko Claude
- Department of Medicine, Université Catholique du Graben, Butembo, Democratic Republic of the Congo
- Daniel Mukadi-Bamuleka
- Institut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo
- Richard Kitenge-Omasumbu
- Programme National d'Urgences et Actions Humanitaires (PNUAH), Ministry of Health of the Democratic Republic of the Congo (DRC), Democratic Republic of the Congo
- Devika Dixit
- Department of Medicine, Division of Infectious Diseases, University of Saskatchewan, Saskatoon, SK, Canada
- François Edidi-Atani
- Institut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo
- Meris Matondo Kuamfumu
- Institut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo
- Junior Bulabula-Penge
- Institut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo
- Fabrice Mambu-Mbika
- Institut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo
- Olivier Tshiani-Mbaya
- Institut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo
- Janet Diaz
- World Health Organization (WHO), Geneva, Switzerland
- Sabue Mulangu
- Institut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo
- Anais Legand
- World Health Organization (WHO), Geneva, Switzerland
- Placide Mbala-Kingebeni
- Institut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo
- Pierre Formenty
- World Health Organization (WHO), Geneva, Switzerland
- Steve Ahuka-Mundeke
- Institut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo
- Jean-Jacques Muyembe-Tamfum
- Institut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo
- Michael T. Hawkes
- Member, Women and Children's Research Institute, University of Alberta, Edmonton, AB, Canada; Department of Paediatrics, University of Alberta, Edmonton, AB, Canada; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada; School of Public Health, University of Alberta, Edmonton, AB, Canada; Distinguished Researcher, Stollery Science Lab, University of Alberta, Edmonton, AB, Canada; Corresponding author at: Department of Paediatrics, University of Alberta, 3-588D Edmonton Clinic Health Academy, 11405 87 Ave NW, Edmonton, AB T6G 1C9, Canada.
- Journal volume & issue
-
Vol. 53
p. 101638
Abstract
Summary: Background: A paucity of data is available on virologic and biochemical characteristics of paediatric Ebolavirus disease (EVD), compared to adults. Methods: We conducted a retrospective chart review of children (7.6 log10copies/mL, alanine transaminase >525 U/L, C-reactive protein >100 mg/L, blood urea nitrogen >7.5 mmol/L, rhabdomyolysis, and.acute kidney injury. Interpretation: Paediatric EVD patients, like adults, experience multiorgan dysfunction with life-threatening electrolyte imbalances, hypoglycaemia, kidney injury, liver injury, and rhabdomyolysis. Paediatric patients have significantly higher VLs throughout the course of EVD than adults. Funding: This study was not funded.
