Revolutionizing deceased donor transplantation: How new approaches to machine perfusion broadens the horizon for organ donation

Abstract

Solid organ transplantation is lifesaving for persons with end-stage organ disease. Thanks to advancements in organ preservation, surgeons are now able to successfully transplant organs that were previously considered high risk for poor graft function. Innovations in perfusion machine types, preservation solutions and additives to preservation solutions have significantly improved the ability to utilize organs previously thought unusable.Newer organ preservation techniques are offering a promising outlook for extending graft longevity and improving transplant outcomes. This review explores the impact of deceased donor type on graft quality and highlights emerging strategies designed to improve the function and viability of deceased donor organs.

Keywords

• Organ donation
• Cold ischemia
• Warm ischemia
• Hypothermic pump perfusion
• Normothermic perfusion
• Perfusate solutions