Nature Communications (Nov 2021)
Efficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitors
- Cho Yeow Koh,
- Norrapat Shih,
- Christina Y. C. Yip,
- Aaron Wei Liang Li,
- Weiming Chen,
- Fathiah S. Amran,
- Esther Jia En Leong,
- Janaki Krishnamoorthy Iyer,
- Grace Croft,
- Muhammad Ibrahim Bin Mazlan,
- Yen-Lin Chee,
- Eng-Soo Yap,
- Dougald M. Monroe,
- Maureane Hoffman,
- Richard C. Becker,
- Dominique P. V. de Kleijn,
- Vaishali Verma,
- Amita Gupta,
- Vijay K. Chaudhary,
- A. Mark Richards,
- R. Manjunatha Kini,
- Mark Y. Chan
Affiliations
- Cho Yeow Koh
- Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore
- Norrapat Shih
- Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore
- Christina Y. C. Yip
- Department of Laboratory Medicine, National University Hospital
- Aaron Wei Liang Li
- Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore
- Weiming Chen
- Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore
- Fathiah S. Amran
- Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore
- Esther Jia En Leong
- Department of Biological Sciences, National University of Singapore
- Janaki Krishnamoorthy Iyer
- Department of Biological Sciences, National University of Singapore
- Grace Croft
- Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore
- Muhammad Ibrahim Bin Mazlan
- Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore
- Yen-Lin Chee
- Department of Haematology, National Cancer Institute
- Eng-Soo Yap
- Department of Haematology, National Cancer Institute
- Dougald M. Monroe
- Division of Hematology/Oncology, University of North Carolina at Chapel Hill
- Maureane Hoffman
- Department of Pathology, Duke University
- Richard C. Becker
- University of Cincinnati
- Dominique P. V. de Kleijn
- Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore
- Vaishali Verma
- Centre for Innovation in Infectious Disease Research, Education, and Training (CIIDRET), University of Delhi South Campus
- Amita Gupta
- Centre for Innovation in Infectious Disease Research, Education, and Training (CIIDRET), University of Delhi South Campus
- Vijay K. Chaudhary
- Centre for Innovation in Infectious Disease Research, Education, and Training (CIIDRET), University of Delhi South Campus
- A. Mark Richards
- Cardiovascular Research Institute, NUHS
- R. Manjunatha Kini
- Department of Biological Sciences, National University of Singapore
- Mark Y. Chan
- Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore
- DOI
- https://doi.org/10.1038/s41467-021-27275-8
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Bleeding complications limits the use of effective antithrombotics therapeutics. Here, the authors developed next-generation direct thrombin inhibitors with low bleeding risks as safe peri-percutaneous coronary intervention anticoagulants when used in combination with antiplatelets.
