A general theoretical framework to design base editors with reduced bystander effects

Qian Wang; Jie Yang; Zhicheng Zhong; Jeffrey A. Vanegas; Xue Gao; Anatoly B. Kolomeisky

doi:10.1038/s41467-021-26789-5

Nature Communications (Nov 2021)

A general theoretical framework to design base editors with reduced bystander effects

Qian Wang,
Jie Yang,
Zhicheng Zhong,
Jeffrey A. Vanegas,
Xue Gao,
Anatoly B. Kolomeisky

Affiliations

Qian Wang: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Physics, University of Science and Technology of China
Jie Yang: Department of Chemical and Biomolecular Engineering, Rice University
Zhicheng Zhong: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Physics, University of Science and Technology of China
Jeffrey A. Vanegas: Department of Chemical and Biomolecular Engineering, Rice University
Xue Gao: Department of Chemical and Biomolecular Engineering, Rice University
Anatoly B. Kolomeisky: Center for Theoretical Biological Physics, Rice University

DOI: https://doi.org/10.1038/s41467-021-26789-5
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 10

Abstract

Read online

Base editors can edit target nucleotides, and identical ones that are within the editing window. Here the authors build an analytical model to propose general principles of editor design to reduce bystander effects.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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