Serum IL-1ra Is Associated with but Has No Genetic Link to Type 1 Diabetes

Paul M. H. Tran; Fran Dong; Khaled Bin Satter; Katherine P. Richardson; Roshni Patel; Lynn K. H. Tran; Diane Hopkins; Ravindra Kolhe; Kathleen Waugh; Marian Rewers; Sharad Purohit

doi:10.3390/endocrines3030048

Endocrines (Sep 2022)

Serum IL-1ra Is Associated with but Has No Genetic Link to Type 1 Diabetes

Paul M. H. Tran,
Fran Dong,
Khaled Bin Satter,
Katherine P. Richardson,
Roshni Patel,
Lynn K. H. Tran,
Diane Hopkins,
Ravindra Kolhe,
Kathleen Waugh,
Marian Rewers,
Sharad Purohit

Affiliations

Paul M. H. Tran: Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, 1120 15th St., Augusta, GA 30912, USA
Fran Dong: Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Mail Stop A-140, 1775 Aurora Court, Aurora, CO 80045, USA
Khaled Bin Satter: Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, 1120 15th St., Augusta, GA 30912, USA
Katherine P. Richardson: Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, 1120 15th St., Augusta, GA 30912, USA
Roshni Patel: Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, 1120 15th St., Augusta, GA 30912, USA
Lynn K. H. Tran: Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, 1120 15th St., Augusta, GA 30912, USA
Diane Hopkins: Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, 1120 15th St., Augusta, GA 30912, USA
Ravindra Kolhe: Department of Pathology, Augusta University, 1120 15th St., Augusta, GA 30912, USA
Kathleen Waugh: Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Mail Stop A-140, 1775 Aurora Court, Aurora, CO 80045, USA
Marian Rewers: Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Mail Stop A-140, 1775 Aurora Court, Aurora, CO 80045, USA
Sharad Purohit: Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, 1120 15th St., Augusta, GA 30912, USA

DOI: https://doi.org/10.3390/endocrines3030048
Journal volume & issue: Vol. 3, no. 3
pp. 570 – 577

Abstract

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Interleukin-1 antagonism is a proposed biomarker and potential therapy for the delay and/or treatment of type 1 diabetes (T1D). We evaluated the role of circulating interleukin-1 receptor antagonist (IL-1ra) in a prospectively monitored cohort of T1D patients. In order to determine a mechanistic association between IL-1ra and T1D, we performed co-localization analyses between serum IL-1ra protein quantitative trait loci and T1D genome-wide analysis studies. Adjusting for human leukocyte antigen (HLA) genotypes, first degree relative status, gender, and age, serum levels of IL-1ra were lower in subjects who progressed to T1D compared to the controls (p = 0.023). Our results suggest that females have higher levels of IL-1ra compared to males (p = 0.005). The 2q14.1 region associated with serum IL-1ra levels is not associated with a risk of developing T1D. Our data suggest that IL-1 antagonism by IL-1ra is not an effective therapy in T1D, but IL-1ra may be a biomarker for progression to T1D.

Published in Endocrines

ISSN: 2673-396X (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology
Website: https://www.mdpi.com/journal/endocrines

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Abstract

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