Metabolomic profiling of samples from pediatric patients with asthma unveils deficient nutrients in African Americans

Hui-Qi Qu; Joseph Glessner; Jingchun Qu; Steven Gilhool; Frank Mentch; Ian Campbell; Patrick Sleiman; John J. Connolly; Hakon Hakonarson

iScience (Jul 2022)

Metabolomic profiling of samples from pediatric patients with asthma unveils deficient nutrients in African Americans

Hui-Qi Qu,
Joseph Glessner,
Jingchun Qu,
Steven Gilhool,
Frank Mentch,
Ian Campbell,
Patrick Sleiman,
John J. Connolly,
Hakon Hakonarson

Affiliations

Hui-Qi Qu: The Center for Applied Genomics, Children’s Hospital of Philadelphia, 3615 Civic Center Blvd, Abramson Building, Philadelphia, PA 19104, USA
Joseph Glessner: The Center for Applied Genomics, Children’s Hospital of Philadelphia, 3615 Civic Center Blvd, Abramson Building, Philadelphia, PA 19104, USA; Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Division of Human Genetics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Jingchun Qu: The Center for Applied Genomics, Children’s Hospital of Philadelphia, 3615 Civic Center Blvd, Abramson Building, Philadelphia, PA 19104, USA
Steven Gilhool: The Center for Applied Genomics, Children’s Hospital of Philadelphia, 3615 Civic Center Blvd, Abramson Building, Philadelphia, PA 19104, USA
Frank Mentch: The Center for Applied Genomics, Children’s Hospital of Philadelphia, 3615 Civic Center Blvd, Abramson Building, Philadelphia, PA 19104, USA
Ian Campbell: The Center for Applied Genomics, Children’s Hospital of Philadelphia, 3615 Civic Center Blvd, Abramson Building, Philadelphia, PA 19104, USA; Division of Human Genetics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Patrick Sleiman: The Center for Applied Genomics, Children’s Hospital of Philadelphia, 3615 Civic Center Blvd, Abramson Building, Philadelphia, PA 19104, USA; Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Division of Human Genetics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA
John J. Connolly: The Center for Applied Genomics, Children’s Hospital of Philadelphia, 3615 Civic Center Blvd, Abramson Building, Philadelphia, PA 19104, USA
Hakon Hakonarson: The Center for Applied Genomics, Children’s Hospital of Philadelphia, 3615 Civic Center Blvd, Abramson Building, Philadelphia, PA 19104, USA; Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Division of Human Genetics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA; Division of Pulmonary Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA; Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland; Corresponding author

Journal volume & issue: Vol. 25, no. 7
p. 104650

Abstract

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Summary: Plasma metabolomics represents a potentially powerful approach to understand the biochemical mechanisms of nutrition and metabolism in asthma. This study aims to acquire knowledge on plasma metabolites in asthma, which may provide avenues for nutrition therapy, as well as explanations for the observed effects in existing therapies. This study investigated 249 metabolites from 18 metabolite groups in a large cohort of African American population, including 602 pediatric patients with asthma and 593 controls, using a nuclear magnetic resonance (NMR) metabolomics platform. Decreased levels of citrate, ketone bodies, and two amino acids histidine (His) and glutamine (Gln), were observed in asthma cases compared to controls. Metabolites for lipid metabolism lost significance after controlling for comorbid obesity. For the first time, this study depicts a broad panorama of lipid metabolism and nutrition in asthma. Supplementation or augmentation of nutrients that are deficient may be beneficial for asthma care.

Published in iScience

ISSN: 2589-0042 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science
Website: http://www.cell.com/iscience/home

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