Protocol for mathematical prediction of patient response and survival to immune checkpoint inhibitor immunotherapy

Abstract

Summary: This protocol describes the application of a mechanistic mathematical model of immune checkpoint inhibitor (ICI) immunotherapy to patient tumor imaging data for predicting solid tumor response and patient survival under ICI intervention. We describe steps for data collection and processing, data pipelines, and approaches to increase precision. The protocol is highly predictive as early as the first restaging after treatment start and can be used with standard-of-care imaging measures.For complete details on the use and execution of this protocol, please refer to Butner et al. (2020)1 and Butner et al. (2021).2 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.

Keywords

• Cancer
• Health Sciences
• Immunology
• Systems biology
• Biotechnology and bioengineering