QUANTITATIVE APPROACH TO ASSESSMENT OF THERAPEUTIC RESPONSE ON EARLY STAGES OF ULCERATIVE COLITIS TREATMENT

Abstract

Research is devoted to the design of a quantitative approach to the assessment of therapeutic response to therapy of patients with ulcerative colitis in the first 5 days of treatment. The study included 48 patients with ulcerative colitis with mild and moderate-severe current disease. Quantitative changes in the severity of the condition of the patient were analyzed using a specially designed questionnaire, including laboratory values and clinical symptoms. It was found that the standard qualitative approach to evaluating the effectiveness of the therapy in patients with ulcerative colitis with multidirectional dynamics of individual clinical symptoms and laboratory parameters in the first 5 days of treatment in most cases does not allow to give an integral characteristic of the general condition of the patient changes. Designed quantitative approach to evaluating therapeutic response to the treatment allow not only identify the minimal changes in patient condition in the first 5 days, but also to predict the effect obtained by the treatment of two weeks.

Keywords

• ulcerative colitis
• evaluation of therapeutic response