Acta Crystallographica Section E (Feb 2010)
6-Fluoro-4-oxochroman-2-carboxylic acid
Abstract
The title compound, C10H7FO4, is an intermediate in the synthesis of the drug Fidarestat, (2S,4S)-2-aminoformyl-6-fluoro-spiro[chroman-4,4′-imidazolidine]-2′,5′-dione. The dihydropyranone ring adopts an envelope conformation with the asymmetric C atom in the flap position. In the crystal, the molecules are linked into zigzag chains along [100] by O—H...O hydrogen bonds and C—H...π interactions involving the benzene ring.