Synthesis and In Vitro Antiparasitic Activity of Novel Arylamine Mannich Base-Type Derivatives against Trypanosoma cruzi and Leishmania spp.

Affiliations

Rocio Paucar-Bernabé: Department of Organic and Pharmaceutical Chemistry, Institute of Tropical Health, Universidad de Navarra, 31008 Pamplona, Spain
Rubén Martín-Escolano: Departamento de Parasitología, Instituto de Investigación Biosanitaria (ibs.GRANADA), Hospitales Universitarios de Granada/Universidad de Granada, 18014 Granada, Spain
Elsa Moreno-Viguri: Department of Organic and Pharmaceutical Chemistry, Institute of Tropical Health, Universidad de Navarra, 31008 Pamplona, Spain
Manuel Sánchez-Moreno: Departamento de Parasitología, Instituto de Investigación Biosanitaria (ibs.GRANADA), Hospitales Universitarios de Granada/Universidad de Granada, 18014 Granada, Spain
Silvia Pérez-Silanes: Department of Organic and Pharmaceutical Chemistry, Institute of Tropical Health, Universidad de Navarra, 31008 Pamplona, Spain

Abstract

Chagas disease and Leishmaniasis are trypanosomatid diseases considered as neglected tropical diseases by the WHO. [...]